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Immune Repertoire Profiling


NGS Services


Advanced Bioinformatics


Cloning


In-vitro screening platforms


Collaborations

MedGenome is committed and available to work with you to support your SARS-CoV-2 and COVID-19 related research and discovery efforts. We applaud your efforts to find solutions to this unprecedented pandemic, and consider all of our collective work on this pandemic essential to advance the research goals, while following the safety recommendations by the public health authorities. We are here to find the most suitable solutions that can help you manage and accelerate your COVID-19-related R&D activities. Here’s how we can help in your research journey.

Therapeutic antibody discovery and disease markers identification

Identify antibody drug candidates using single cell profiling

  • Single-cell BCR (antibody) sequencing from COVID-19 recovered patients and animal models
    1. Paired BCR chains (antibodies) against SARS-CoV-2 antigens for antibodies – drug discovery (Contact us for sample processing and protocols)
    2. Bulk BCR profiling and analysis to understand adaptive immune response
  • Single-cell TCR sequencing to study COVID-19 T-cell responses from COVID-19 recovered patients and animal models
    1. Paired TCR α/β information in SARS-CoV-2 antigen-specific T cells with or without in vitro expansion (Contact us for sample processing and protocols)
  • Bulk TCR profiling to monitor immune profiles from tissues and peripheral blood (Click here to watch a webinar on TCR)

NGS services to study the viral and host genomes for infection and disease susceptibility

  • Bulk RNA sequencing of viral genome
  • Host genome sequencing, variant calling and annotation in key pathway genes
  • Advanced genome assembly and annotation of virus and host genome
  • Targeted gene panels for diagnostics and infection susceptibility alteration assessment
  • Four digit HLA typing and expression to identify polymorphisms related to disease severity

Bioinformatics and population genomics research support

  • Data analysis portal for integrated and interactive analytics on genomics assays
  • Custom bioinformatics analysis available including the ability to integrate genomics and phenotypic analysis data to support SARS-CoV-2 research initiatives
  • Customized genotyping array capturing common and rare ACE2 and TMPRSS2 coding variants for exploring host genetics
  • Click here to access our recent publication on COVID-19

Cloning and In-vitro assays to test antibody and vaccine candidates

  • Cloning, site-directed mutagenesis and expression of viral proteins
  • Cloning of antibody genes
  • Expression of antibody candidates either identified by single cell sequencing or user supplied
  • Screening binding of antibodies to target proteins

In-vitro immunogenicity screening platforms

  • CD8 & CD4 T-cell activation assays for screening potential vaccine candidates
  • CTL activity directed to viral epitopes

Collaborations to collect and interpret data for faster discovery of COVID-19 solutions

  • We can support your experimental goals and assist you with experimental / published data collection, management and interpretation - to fast track your discoveries towards publications and contributions to therapeutic pipelines
    1. Includes MedGenome and client generated data

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