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Clinical and Genomic Features of Androgen Indifferent Prostate Cancer

Jack Masur, Aakrosh Ratan, Krzysztof Wierbilowicz, Adanma Ayanambakkam, Michelle L Churchman, Laura S Graham, George Daniel Grass, Sumati Gupta, Sean Q Kern, Jennifer King, Zin Myint, Robert J Rounbehler, Bodour Salhia, Eric A Singer, Yousef Zakharia, Bryce M Paschal, Paul V Viscuse

Int J Mol Sci. Jan 15, 2025;26(2):679

PMID: 39859392

Androgen-indifferent prostate cancer (AIPC) is increasingly common and particularly lethal. Data describing these tumors are sparse, and AIPC remains a poorly understood malignancy. Utilizing the Oncology Research Information Exchange Network (ORIEN) database, we enriched for tumors with features of AIPC using previously described characteristics. Our AIPC cohort included three subgroups: aggressive variant prostate cancer (AVPC), neuroendocrine PC (NEPC), and double-negative PC (DNPC).

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