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Cost-efficient HIV-1 drug resistance surveillance using multiplexed high-throughput amplicon sequencing: implications for use in low- and middle-income countries

Halime Ekici, Shwetha D. Rao, Anders Sönnerborg, Vedam L. Ramprasad, Ravi Gupta and Ujjwal Neogi (2014). J. Antimicrob. Chemother., 69 (12), 3349-3355.

Increased trends of primary drug resistance mutations (DRMs) among treatment-naive HIV-1-infected patients in low- and middle-income countries (LMICs) and the non-availability of pre-antiretroviral therapy (ART) genotypic resistance testing (GRT) may severely affect future therapeutic outcomes. The main objective of this study was therefore to develop a simplified, cost- and labor-efficient but high-throughput GRT protocol to be applied in the large-scale surveillance of DRMs in LMICs.

  https://academic.oup.com/jac/article/69/12/3349/818342/Cost-efficient-HIV-1-drug-resistance-surveillance

 

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