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High rate of detected variants in male PLCZ1 and ACTL7A genes causing failed fertilization after ICSI

Hum Reprod Open, Vol. 2024, Issue 4, Article Number: hoae057, 2024

PMID: 39411542

What is the frequency of PLCZ1, ACTL7A, and ACTL9 variants in male patients showing fertilization failure after ICSI, and how effective is assisted oocyte activation (AOA) for them?. Male patients with fertilization failure after ICSI manifest variants in PLCZ1 (29.09%), ACTL7A (14.81%), and ACTL9 (3.70%), which can be efficiently overcome by AOA treatment with ionomycin.

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