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Immunodominant T‑cell epitopes from the SARS‑CoV‑2 spike antigen reveal robust pre‑existing T‑cell immunity in unexposed individuals

Scientific Reports, (2021) 11:13164

The COVID‑19 pandemic has revealed a range of disease phenotypes in infected patients with asymptomatic, mild, or severe clinical outcomes, but the mechanisms that determine such variable outcomes remain unresolved. In this study, we identified immunodominant CD8 T‑cell epitopes in the spike antigen using a novel TCR‑binding algorithm.

  https://rdcu.be/cm3qa

 

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