full-length sequencing of TCR and BCR

Identification of all clonotypes in a diverse repertoire of T-Cell receptors and B-Cell receptors

TCR and BCR profiling enables comprehensive mapping of the immune repertoire. It has a number of applications including understanding disease mechanisms, characterizing immunological responses, biomarker identification and development of immunotherapies. This is exemplified by the success of several immunotherapies in cancer treatment and the development of therapeutic antibodies.

Next-generation sequencing (NGS) technologies now enables accurate and unbiased profiling of TCRs and BCRs with relative ease. In combination with other assays, it can serve as prognostic and response markers. At MedGenome, we provide RNA based TCR and BCR repertoire profiling services for bulk and single cell analysis.

Read the technical sheets

Immune profiling services

Explore the immune repertoire across species

SMARTer TCR α/β– Human, Mouse, rat and non-human primates.

10x Single cell TCR and BCR – Human, mouse and rat.

SMARTer BCR IgG H/K/L – Human and Mouse.

Immune Profiling Analysis

Quantify and characterize T-cell and B-cell clonotypes with publication ready visualization

Explore our analysis report

Streamlined pipeline for fast & scalable analysis.
Customized reporting.
Interactive reports.
Publication-ready figures.
Improve data interpretation with support from MedGenome's team of experts.

Our analysis pipeline incorporates Takara’s Immuneprofiler and VDJ tools for bulk T-Cell and B-Cell receptor sequencing. For single cell, we use 10x Genomics cellranger and state-of-the-art published algorithms for characterizing the immune repertoire. In addition, comprehensive reports provide

Full-length Clonotype sequences and their frequencies.
Diversity scores for each sample.
V and J gene usage.
Paired heavy and light chain sequences (single cell sequencing).
Phylogenetic analysis of clonotypes of interest.

Learn more

Service highlights

Solutions for cells, tissues and blood with varying inputs for quality and quantity.

Support with experimental design and selection of appropriate application.

Higher sensitivity in detecting low frequency TCRs/BCRs including samples with low input.

End-to-end solutions for extraction, sample QC, library preparation, sequencing and bioinformatics analysis.

Accurate representation of expressed TCRs/BCRs vs non-functional TCRs/BCRs with improved ability to call novel and low frequency clones.

Resources

White papers and technical resources

Video

TCR and BCR Report Walkthrough

Watch video

Whitepaper

MedGenome's TCR repertoire profiling solutions

Download white paper

services

Other services you'll be interested in

Transcriptomics services
Spatial transcriptomics
WGS/WES services

Transcriptomics services

Vast experience and expertise in generating high-quality data from degraded RNA samples.
Supported by custom and advanced bioinformatics analytics.

Learn more

Spatial transcriptomics

10X Visium for spatial transcriptome profiling of fresh frozen and FFPE tissue sections.
Tissue annotation supported by expert pathologists.

Learn more

WES/WGS

Cost effective whole genome/exome services with expedited turn-around times.

Learn more

TESTIMONIALS

"Always very quick responses, wonderful turnaround times and exemplary quality of service. Data is always great, and any issues are always resolved. The price is competitive, stable and reliable. There's no problem that the MedGenome team hasn't solved yet."

– Cassie Pond, The Feinstein Institutes for Medical Research

TESTIMONIALS

"We are examining the results. Very exciting. My compliments — you make the best summary report I have seen."

– Dr John Castle, Sr. Director, Bioinformatics, Agenus

TESTIMONIALS

"We have been working with MedGenome on identification of novel oncogenic mutations and exome anlaysis of tumor cells. Our collaboration has been extremely productive. We are extremely happy with their commitment towards research and development in general"

– Dr Krishnaraj Rajalingam, Heisenberg Professor in Cell Biology, Mainz University, Germany

TESTIMONIALS

"We have been working with MedGenome on genomics-based diagnostics and research for many years now. We are extremely happy and pleased with the quality, the skill and the pro-activeness of the firm. No wonder that it has grown to be a leading genomics service provider."

– Dr Radha Rama Venkatesan, Executive Scientific Officer, Molecular Genetics, MDRF

how to order

Starting a project with MedGenome

MedGenome's customer portal allows for easy sample submission and sample tracking during lab processing. Using our portal ensures data QC, raw data and interactive analysis reports are delivered securely.

Our process is simple

Request a quote

We create your project

Upload sample details

Submit documents and ship samples

We process and analyze your samples

Your data is delivered to you

News

Work with the multiomics specialists

Fields marked * are mandatory

Multiomics Services

Research & Pharma Solutions

Resources

About

Contact

MedGenome Appoints Industry Veterans Felix Olale, M.D., Ph.D., as CEO and Jennifer Rose as Chief Commercial Officer to Lead U.S. Expansion

MedGenome, in collaboration with PacBio, announces a de novo genome assembly and annotation grant

MedGenome's genomics solutions for precision medicine

MedGenome, in collaboration with PacBio, announces a de novo genome assembly and annotation grant

Decode TCR and BCR repertoire

Identification of all clonotypes in a diverse repertoire of T-Cell receptors and B-Cell receptors

Explore the immune repertoire across species

Quantify and characterize T-cell and B-cell clonotypes with publication ready visualization