MedGenome, a genomics-driven research and diagnostics company, today announced the appointment of Dr. Andrew Peterson as its Chief Scientific Officer.
Dr. Peterson will lead the company’s research programs to identify drug targets and biomarkers by leveraging its unparalleled access to south Asian cohorts and disease phenotypes. Its large network of collaborations with hospitals across India has enabled MedGenome to create a research platform to tap into thousands of patient records with oncology, auto-immune, metabolic and rare disease diagnoses. The platform capabilities are amplified by MedGenome’s high-throughput genomics sequencing and data analysis/interpretation capabilities. Dr. Peterson will also be instrumental in strengthening the organization’s capabilities and capacities to perform and execute large scale genomics research projects.
Prior to joining MedGenome, Dr. Peterson was Senior Director of Molecular Biology at Genentech, primarily focused on genomics applications for therapeutic interventions in areas such as cardiovascular diseases and liver diseases, resulting in molecules in clinical development.
Scientists from MedGenome, Bangalore, India in collaboration with oncologists from Tata Memorial Hospital, Mumbai, India and scientists at Genentech, a member of the Roche Group, South San Francisco, Calif., USA, report in Cancer Cell the identification of a treatable mutation linked to lung cancer. A mutation in HER2, a gene normally amplified in breast cancer, was found mutated in a familial lung cancer patient. Based on the mutation profile the patient was treated with an approved HER2 inhibitor that normally is used for treating breast cancer. The study also reports several additional actionable activating HER2 mutations in multiple cancers in the same region of HER2 as observed in the lung cancer patient.
The published study examines the feasibility of treating Lynch syndrome using a personalized cancer vaccine approach by identifying potential immunogenic tumor specific alterations.
Lynch syndrome is a hereditary cancer arising from loss of function mutations in DNA mismatch repair genes, such as MLH1, MSH2, MSH3, MSH6, PMS2, and EPCAM. “Over 1 million Americans are affected by Lynch syndrome according to the Cancer Moonshot Blue Ribbon Panel, wherein only 5% are aware of this” said Prof Henry T. Lynch whose groundbreaking research in 1960s led to the discovery of cancer family syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) also referred to as Lynch syndrome.
MedGenome’s OncoPept™ platform of advanced genomics-based solutions designed to accelerate cancer immune-oncology research, was named the winner of the 2018 MedTech Breakthrough Awards for ‘Best Overall Genomics Solution.’