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A Synthetic DNA, Multi-Neoantigen Vaccine Drives Predominately MHC Class I CD8(+) T-cell Responses, Impacting Tumor Challenge

Cancer immunology research, Vol. 7, Issue 2, Pages 174-182, 2019

PMID: 30679156

T-cell recognition of cancer neoantigens is important for effective immune-checkpoint blockade therapy, and an increasing interest exists in developing personalized tumor neoantigen vaccines. Previous studies utilizing RNA and long-peptide neoantigen vaccines in preclinical and early-phase clinical studies have shown immune responses predominantly driven by MHC class II CD4(+) T cells.

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  https://www.ncbi.nlm.nih.gov/pubmed/30679156

 

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