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Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations

Nature genetics, Vol. 48, Issue 4, Pages 407-416, 2016

PMID: 26928227

We analyzed transcriptomes (n = 211), whole exomes (n = 99) and targeted exomes (n = 103) from 216 malignant pleural mesothelioma (MPM) tumors. Using RNA-seq data, we identified four distinct molecular subtypes: sarcomatoid, epithelioid, biphasic-epithelioid (biphasic-E) and biphasic- sarcomatoid (biphasic-S).

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  https://www.ncbi.nlm.nih.gov/pubmed/26928227

 

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