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Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma

FEBS letters, Vol. 593, Issue 1, Pages 23-41, 2018

PMID: 30417337

Retinoblastoma (RB) is a childhood eye cancer. Currently, chemotherapy, local therapy, and enucleation are the main ways in which these tumors are managed. The present work is the first study that uses constraint- based reconstruction and analysis approaches to identify and explain RB- specific survival strategies, which are RB tumor specific. Importantly, our model-specific secretion profile is also found in RB1-depleted human retinal cells in vitro and suggests that novel biomarkers involved in lipid metabolism may be important. Finally, RB-specific synthetic lethals have been predicted as lipid and nucleoside transport proteins that can aid in novel drug target development.

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  https://www.ncbi.nlm.nih.gov/pubmed/30417337

 

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