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Serum starvation of ARPE-19 changes the cellular distribution of cholesterol and Fibulin3 in patterns reminiscent of age-related macular degeneration

Experimental cell research, Vol. 361, Issue 2, Pages 333-341, 2017

PMID: 29097185

Retinal pigment epithelium (RPE) has been implicated as key source of cholesterol-rich deposits at Bruch’s membrane (BrM) and in drusen in aging human eye. We have shown that serum-deprivation of confluent RPE cells is associated with upregulation of cholesterol synthesis and accumulation of unesterified cholesterol (UC).

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  https://www.ncbi.nlm.nih.gov/pubmed/29097185

 

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