Frontiers in immunology, Vol. 9, Pages 188, 2021

PMID: 33746956

Major histocompatibility complex (MHC) class II deficiency is a rare autosomal recessive form of primary immunodeficiency disorder (PID) characterized by the deficiency of MHC class II molecules. This deficiency affects the cellular and humoral immune response by impairing the development of CD4(+) T helper (Th) cells and Th cell-dependent antibody production by B cells.

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  https://www.ncbi.nlm.nih.gov/pubmed/33746956