Publications
Immunodominant T‑cell epitopes from the SARS‑CoV‑2 spike antigen reveal robust pre‑existing T‑cell immunity in unexposed individualsLearn more
Research Services Blog
June 2021: Multi-omic profiling: Combining epigenomics and gene expression in a single cellLearn more
Immuno-Oncology Research and Biomarker Discovery
Cancer immunotherapy is now an established therapeutic modality in Cancer. At MedGenome, we offer solutions for tumor microenvironment analyses, and TCR repertoire analysis, enabling novel drug target discovery, patient selection for clinical trials, and identification of biomarkers for immune responsiveness of the tumor microenvironment.
Next Generation Sequencing and Data Analysis
MedGenome offers end-to-end solutions for next-generation sequencing based assays for a wide range of sample types (such as DNA, RNA, PBMCs, purified CD4 and CD8+ T-cells, splenocytes, TILs, T-cell lines and B-cells). We have extensive experience working with low quality / low quantity samples such as from FFPE tissues and can generate good-quality data and support basic and advanced data analysis. In addition to generating high quality data, we also support our customers with advanced and publication-ready data analysis outputs such as gene expression/differential gene expression analysis, clonotypes and V(D)J sequence comparison heatmaps for TCR and BCR, as well as cell type identification and gene signature building from single cell genomics data.
Large Scale Genetic Studies in South Asia
Most studies that research the interplay between disease and genes have focused on European populations. The reference genomes created through various sequencing studies – which form the foundation of genetic interpretation and insights provided to patients and consumers - have also focused on such populations, making them less useful for Asian populations. MedGenome has led the adoption of genetic diagnostics and research in India and South Asia in the past few years, which enables us to leverage the genetic richness embedded in South Asia’s population isolates for discovery. With high-throughput data generation and analysis capabilities at scale, MedGenome wants to partner with bio-pharma on large-scale research projects to advance personalized medicine for complex human diseases.
Resources
White Papers: Denovo Genome Assembly Solutions at MedGenome View more
QC Reports: Whole-genome Sequencing/Whole-exome Sequencing Sample QC Report View more
Publications: Immunodominant T‑cell epitopes from the SARS‑CoV‑2 spike antigen reveal robust pre‑existing T‑cell immunity in unexposed individuals View more
Posters: Multiple Platforms for Single Cell Genomics to Enable Biomarker Discovery in Immunotherapy View more
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Partner With Us
MedGenome is a global leader in personalized medicine with unique genomic solutions in immuno-oncology, diabetes, ophthalmology and rare diseases. It has a high-throughput NGS facility in Foster City, California, supporting research projects for bio-pharma and academic institutions in the US, Canada and Europe.
With expertise in sample & library preparation for various assays including whole exome, whole genome, total/small transcriptome, single cell gene expression, TCR, CITE-seq, ATAC and CUT&TAG, MedGenome is able to partner with clients on biomarker identification and target discovery projects. Our advanced genomic data analysis capabilities and insights into South-Asian specific variants make us a preferred partner for bio-pharma clients.
Our genomics team is also able to partner with manufacturers to incorporate genetic insights into their assay development.
To know more about the value MedGenome provides to your research, click here
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- Large Scale Genetic Studies in South Asia
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